Fri Dec 13 2024

53 articles - From Friday Dec 06 2024 to Friday Dec 13 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

J Hepatol

The 2024 updated WHO guidelines for the prevention and management of chronic hepatitis B: main changes and potential implications for the next major liver society clinical practice guidelines.

Yet, the European, American and Asian regions encompass multiple low, middle and intermediate-income countries with high HBV endemicity and vulnerable populations that should benefit from simplified clinical algorithms. Here, from an analysis of the WHO guideline development process and its new recommendations, we aimed to identify the anticipated areas of agreements and controversies with the next liver society hepatitis B guidelines which will have to balance clinical risks and benefits for the patients.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Mortality of Acute Kidney Injury in Cirrhosis: A Systematic Review and Meta-Analysis of Over 5 Million Patients Across Different Clinical Settings.

AKI substantially affects the prognosis of patients with cirrhosis, especially those in ICU and/or with ACLF. Prognosis is also greatly influenced by the AKI stage, timing of onset and diagnostic criteria.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

In-Hospital Screening Campaign Against Hepatitis C Could Be Effective for Identifying More Patients Who Still Need Treatment.

The non-negligible prevalence of patients with a positive viral load among an unselected group of hospitalised patients suggests that such settings could effectively enhance screening programmes aimed at HCV elimination. Additionally, this approach may help identify patients who are not currently included in the National Recommendations.

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Leucine-Rich Alpha-2 Glycoprotein Is Associated With Transmural Inflammation Assessed by Intestinal Ultrasound in Patients With Crohn's Disease.

LRG showed a robust correlation with IUS scores, suggesting its potential as a novel indicator for targeting transmural healing in patients with CD.

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Am J Gastroenterol

Effectiveness of Ustekinumab for patients with moderate to severe Ulcerative Colitis: A Multi-Center Real-World Canadian Study.

In a highly refractory and largely bio-exposed population, a substantial proportion of patients with UC treated with ustekinumab can achieve clinical and endoscopic outcomes of importance after 12 months. Prior biologic exposure is associated with lower rates of endoscopic remission.

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Clin Gastroenterol Hepatol

The Impact and Interactions of Race and Gender on Healthcare Use and Spending Irritable Bowel Syndrome.

Overall and IBS-related spending is higher in women, but gender differences in IBS-related care are small. Racial/ethnic comparisons show reduced spending in Asian and Hispanic patients, increased ED care in Black patients, and variations in spending patterns. Gender disparities differ by race.

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Endosc Int Open

Endoscopic submucosal dissection of colorectal pedunculated polyps.

ESD achieved high en bloc and R0 resection rates for large pedunculated polyps. In our collective, up to 32% of polyps already had adenocarcinoma, resulting in a high curative resection rate due to complete resection and subsequently accurate risk classification.

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Endoscopy

Optical assessment of scars after endoscopic mucosal resection of large colorectal polyps in a multicenter, community hospital setting: is routine biopsy still necessary?

Based on this multicenter community hospital study, routine tattoo placement and scar biopsies of the post-EMR scar can be omitted. Assessment of post-EMR scars by dedicated endoscopists is advised.

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Gut

Butyrate-producing <i>Faecalibacterium prausnitzii</i> suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway.

In addition, metabolomics, RNA sequencing, chromatin immunoprecipitation sequencing, Western blot analysis, immunohistochemistry and lentiviral-mediated gene knockdown system were used to elucidate the underlying mechanisms. Results We first unveiled significant gut microbiota dysbiosis in NKTCL patients, prominently marked by a notable reduction in to ameliorate this malignancy.

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Endoscopic papillectomy versus surgical ampullectomy for adenomas and early cancers of the papilla: a retrospective Pancreas2000/European Pancreatic Club analysis.

The rate of patients with poor indications due to non-neoplastic disease or advanced cancer is still high for both EP and TSA; multiple retreatments were necessary for EP. Although EP can be considered an appropriate primary therapy for certain ampullary adenomas, case selection for both therapies (especially with regard to the best step-up approach) should be studied further.

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Hepatology

Distinct immune microenvironment of venous tumor thrombus in hepatocellular carcinoma at single-cell resolution.

TAMs, especially C5aR+ TAMs, were enriched in PVTT. C5aR+ TAMs contribute to the development of PVTT and poor prognosis by reshaping the immunosuppressive environment.

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Enhanced hepatitis B virus-specific immunity by combined neutralizing antibody therapy and DNA vaccination in a murine model of chronic hepatitis B infection.

Although the combination therapy did not result in a functional cure, our findings indicate it produced additive effects on the development of HBV-specific T cells in the liver immediately following treatment, offering a better insight into the mechanisms underlying hepatic tolerance.

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Modulatory effects of CNNM4 on Protein-L-Isoaspartyl-O-Methyltransferase repair function during Alcohol-Induced hepatic damage.

These findings shed light on the dysregulation of Mg2+ homeostasis in ALD, providing a promising therapeutic approach targeting CNNM4. GalNAc siCnnm4 therapy boost the repair processes of ethanol damaged proteins through the upregulation of PCMT1 activity.

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Outcome and management of patients with hepatocellular carcinoma who achieved a complete response to immunotherapy-based systemic therapy.

Overall survival and recurrence-free survival of patients with CR-mRECIST-only and CR-RECISTv1.1 were excellent, and 6 of 7 patients with CR-mRECIST-only who underwent surgical conversion therapy had pathological CR. Despite potential limitations, these findings support the use of mRECIST in the context of immunotherapy for clinical decision-making. When considering ICI discontinuation, treatment for at least 6 months beyond CR seems advisable.

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Stard1 promotes cholestatic liver injury and disease progression by sensitizing to bile acid hepatotoxicity.

These findings highlight a role for STARD1 in cholestatic liver injury and suggest that its targeting may be of relevance for CLD.

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Unraveling bidirectional evolution of unstable mitochondrial DNA mutations in hepatocellular carcinoma at single-cell resolution.

Our study unravels the landscape of single-cell somatic mtDNA mutations in HCC tissues and reveals the bidirectional evolution of unstable mtDNA mutations, with potential implications for HCC stratification and therapeutic intervention.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: H. pylori Antimicrobial Susceptibility Testing-An Expanding Toolbox.

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Editorial: Mesenchymal Stem Cell Therapy for Perianal Fistulising Crohn's Disease-Effective or Hype?

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Gastrointest Endosc

A note from the Editor-in-Chief.

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Endoscopic submucosal dissection of the cervical esophagus: same but different.

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Underwater colorectal endoscopic submucosal dissection: Should we be submarine voyagers?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Antivirals in Preventing Perinatal Transmission of Hepatitis B: Start and Stop Times are Shifting.

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Arsenic Exposure in Celiac Disease: The Hidden Cost of a Gluten-Free Diet.

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Comment on "Gallstone Disease Is Associated With an Increased Risk of Inflammatory Bowel Disease: Results From 3 Prospective Cohort Studies".

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Metoclopramide May Not Decrease the Need for Second-Look Esophagogastroduodenoscopy in Patients With Overall Active Upper Gastrointestinal Bleeding.

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Response to Borup et al.

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Shared Decision Making in EoE.

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Supplementary Considerations on the Timing of Direct Oral Anticoagulants Resumption.

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Clin Gastroenterol Hepatol

A Roadmap to a Successful Job Search for Gastroenterology Trainees.

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Gastroenterology

A win-win solution: remarkable reversal of foot necrosis in ulcerative colitis.

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Gastrointest Endosc

Gastric cancer prevention and screening during pancreatic cancer screening in high-risk individuals: An opportunity not to be missed.

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Gut

Time for arginine methylation: PRMT5 inhibition to advance cholangiocarcinoma treatment.

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Hepatology

Letter to editor: Use of HBV RNA and to predict change in serological status and disease activity in CHB.

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Letter to the Editor: Refining the role of HAF in hepatocellular carcinoma.

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Reply: Refining the role of HAF in hepatocellular carcinoma.

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The "shell game" after objective response in patients with advanced HCC treated with immunotherapy.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Helicobacter pylori Antimicrobial Susceptibility Testing-An Expanding Toolbox. Authors' Reply.

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Editorial: Mesenchymal Stem Cell Therapy for Perianal Fistulising Crohn's Disease-Effective or Hype? Authors' Reply.

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Letter: Real-Life Evaluation of Effectiveness of Mesenchymal Stem Cell Treatment in Fistulising Crohn's Disease Emphasises Importance of Appropriate Patient Selection and Centre Expertise-Authors' Reply.

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Letter: Real-Life Evaluation of Effectiveness of Mesenchymal Stem Cell Treatment in Fistulising Crohn's Disease Emphasises the Importance of Appropriate Patient Selection and Centre Expertise.

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Letter: Should HBV Therapy Be Stopped Based on HBsAg Level Alone?

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Letter: Should HBV Therapy Be Stopped Based on HBsAg Level Alone? Authors' Reply.

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Gastroenterology

Comment on "Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis".

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Fazirsiran Unveiled: Methodological Considerations for Optimizing Treatment in Alpha-1 Antitrypsin Deficiency.

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Optimizing Methodological Rigor and Evidence Reporting in Brain-Gut Behavioral Treatments for Irritable Bowel Syndrome: Enhancing the Credibility of Network Meta-Analyses.

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Gastrointest Endosc

Accurate predictors for the evaluation of incidental common bile duct dilation.

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Characteristics of factors for metachronous risk after endoscopic resection of serrated polyps.

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J Hepatol

Control compounds for drug-induced liver injury evaluation: Evidence from Database of Adverse Event Notifications.

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Correspondence on "Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD".

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Fecal Microbiota Transplantation in a Long-Standing Auto-Brewery Syndrome with Complex Symptomatology.

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Pharmacological inhibition of ATGL as therapeutic approach for MASH: Far beyond the lipase suppression role of ATGL inhibitors.

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Reflections on HBV Adaptation and Immune Interactions: Insights and Future Directions.

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Response to: Highlighting the Impact of Hormonal Factors on Hepatic Cystogenesis: Implications for Pathophysiology and Clinical Practice.

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